Monocytes in COVID-19: the great influencer of disease severity? What can we learn from databases and existing administrative data? Mapping cerebellar connectivity in neurodevelopmental disorders, Markers in Neuropsychiatric Disorders (MiND) study, Massively Parallel Optical Imaging of Cognition Events in Neuronal Networks in Freely Behaving Mice, Melbourne Genomics Health Alliance Congenital Deafness Flagship, Melbourne Neuropsychiatry Centre Research, Modelling Epilepsy and Epilepsy Drug Effects–Computational Neuroscience Project. Students are supervised and mentored by a research scientist, and work alongside other staff and students in the laboratory team. ‘Find and Follow’: scoping the data capture, reporting and follow-up of (i) pregnancies complicated by congenital abnormalities, (ii) health and development among ‘high risk’ newborns, A parallel group, blinded, placebo controlled, ranDomised pRagmatic clinical trial investigating the Effect of temazepAM on objective and subjective measures of sleep in critically ill patients (The DREAM trial), Anaesthesia, Perioperative and Pain Medicine, Professor and Head, APPMU; Director, Melbourne Clinical and Translational Science Research Platform (MCATS) David Story, Asia Pacific Research Accelerator (APRA) Program, Principal Investigator Professor George Braitberg AM, COVID-19 and the common cold: does pre-existing immunity to seasonally circulating coronaviruses influence the severity of COVID-19, Cultural Respect Encompassing Simulation Training (CREST), Head of Research Program Professor David Story, Development of an automated web-based screening system for eye diseases, Diagnosis, Management and Outcomes of Depression in the Primary Care Setting (The Diamond 10-year Cohort Study), Focused cardiac and lung ultrasound in clinical care, Fostering Health: Examining health care systems for children and young people in Out-of-Home Care, Honorary Research Fellow Dr Susan Webster, International Register of Meta-Research (IRMR), Principal Investigator Dr Georgina Imberger, Investigating the effects of GM-CSF and M-CSF derived human macrophages on phagocytosing P. falciparum infected erythrocytes and cytokine production, Joseph Epstein Centre for Emergency Medicine Research, Director, JECEMR Professor Anne-Maree Kelly, Let's talk about medical research: research equity for Culturally and Linguistically Diverse (CALD) patients. Research candidates seeking to undertake a PhD, Masters by Research or Master of Philosophy can look for potential research topics through the following resources: Research Expertise Student research projects are diverse and available for honours, masters and PhD students. “Glass Brain” 3D brain mapping in health and disease. Is there a role for adipose (fat) tissue in malaria? Other projects may be available. Psychosocial determinants of health in infants & preschool children with Cystic Fibrosis diagnosed via newborn screening, R E Ross Trust Regional Child Health Fellowship Program. in Symposiums and conferences 15+ Medical Research Proposal Templates 1. Does weekly iron supplementation increase iron uptake in pregnant Vietnamese women, and improve maternal and infant health? Use of tools to detect medication related problems in emergency departments, Using Artificial Intelligence to improve the diagnostic predictions of corneal topography machines for Keratoconus subjects, Using Marrow Adipose Tissue to Diagnose Osteoporosis and Predict Fragility Fractures, Using Wearable Activity Trackers to Monitor Physical Activity in Older Adults Undergoing Exercise Interventions for Falls, Vascular remodeling in patients with Mycobacterium ulcerans infection and its effect on wound healing, Your Muscles Matter – The Sarcopenia Study, A monoclonal antibody (mAb1F5) has been developed that identifies the expression of a putative growth factor, Project Leader Associate Professor Warrick Teague, A phase I/II double-blind, randomised controlled trial assessing effect of medicinal cannabis on overall quality of life for people with cancer, A randomised controlled trial of short-course antibiotics in children with cancer and febrile neutropenia, A systematic review of end of life quality of care indicators, A systematic review of the management of anxiety in palliative cancer patients, A systematic review of the management of nausea unrelated to cancer treatment, A systematic review of the management of sleep in palliative care cancer patients, A therapeutic strategy for killing cancer cells by DNA repair inhibition, Academic Department of Surgery, Western Health, An anti-calcitonin receptor (CTR) antibody for the detection of programmed cell death: the role of CTR in a novel adaptive response in a pre-apoptotic mechanism, Analysis of circulating microRNAs in patient serum as a non-invasive biomarker platform, Boussioutas Laboratory: Gastrointestinal Cancer, Brain Cancer Microenvironment and Biology Laboratory, Buchanan laboratory: Oncogenomics (colorectal cancer), Head of Laboratory Associate Professor Daniel Buchanan, Head of Laboratory Professor Lachlan Coin, Cancer drug discovery by inhibition of a DNA repair pathway with Crispr/Cas9 gene editing and biochemistry, Cancer Immunotherapy symptoms: the experience and expectations around management, Program Trial Coordinator Leeanne Pasanen, Research Program Leader Professor Jon Emery, Cardiovascular and Tumourivascular Laboratory, Centre for research excellence in cervical cancer control, Characterisation of complex structural variation in bacterial and human genomes, Group Lead, Cancer Bioinformatics Professor Lachlan Coin, Characterising Respiratory Infections in Immune-suppressed Haematology and Transplant Patients, CHEST Australia Trial: An Intervention to Reduce Time-to-Consult with Symptoms of Lung Cancer, Circulating Biomarkers in Liver Malignancy, CRISP-DNA: The feasibility of assessing bowel cancer risk using genomic testing to target screening in general practice, Herman Professor of Primary Care Cancer Research Professor Jon Emery, Defining the Role of Transcriptional Stress Pathways in Cancer Cell Resistance Towards Anti-Cancer Therapeutics, Developing clinical genomic methods for cancer of unknown primary, Development and validation of triage guidelines for colonoscopy and gastroscopy, The Psychosocial Health and Wellbeing Research (emPoWeR) Unit, Enhance: A multi-centre, randomised phase IV study, Enteric Neuropathy as a Target to Alleviate Gastrointestinal Side-effects of Chemotherapy, Establishing patterns of primary health care usage in cancer at the end of life, Evaluating molecular biomarkers of anal cancer risk, Fertility After Cancer Predictor (FoRECAsT) Study, Fertility decision tools for young women with breast cancer, Fertility preservation in children and teenagers with cancer, Fertility preservation in children with cancer, Finding a needle in the haystack: ctDNA detection for tracking cancer evolution and refining cancer risk, Function and cryo-EM structure of the breast cancer predisposition gene BRCA1, Genomic tools for diagnosis of the presence of a solid tumour and for prediction of tumour subtype and likely treatment response from circulating tumour DNA, Genomic tools for rapid diagnosis of bacterial infection using host and bacterial biomarkers, Gynaecology Research Centre - Hickey Group, Research Group Leader Professor Martha Hickey, Harnessing novel immunotherapies to restore immunity in chronic lymphocytic leukaemia, Head and Neck Tumour Stream Research Group, Heterogeneity of treatment response in advanced cancer: role of intrinsic and microenvironmental factors, Hollande laboratory: Tumour Heterogeneity in Metastatic Cancer, Head of Laboratory Professor Fred Hollande, Host responses to therapy and the tumour microenvironment contribute to the development of tumour resistance, Identification and Characterisation of Molecular Mediators of Cancer Metastasis, Identification of biomarkers to novel therapies in Myelodysplasia, Identifying and characterising Lynch syndrome within the population. The establishment of the Medical Research Future Fund by the Australian Government, for example, offers the promise of continued durable investment in HMR and innovation, and the NHMRC’s substantial investment in research training scholarships for current students and recent graduates signals the Government’s commitment to developing clinician researchers for the future. Available research projects We offer hundreds of research projects, catering to the needs of students with an interest in both basic and translational research. What role does Bax play during gonocyte transformation into spermatogonial stem cells? For Researchers ... 2020 Medical Student Research Conference and Showcase . Ensuring our research makes a difference is a key part of our ethos and research strategy. Year 3 medical students are ineligible to apply due to the adjustment of the teaching schedule that overlaps with the summer research program. School Research Themes. Defining the role of embryo implantation failure in infertility and IVF success. Regulating the vascularisation of the human glomerulus in vitro. » Research » Research projects » The influence of 'Scrubs' on medical students' clinical practice The influence of 'Scrubs' on medical students' clinical practice This MBBS research project investigated how the popular television sitcom Scrubs influenced medical students' perceptions, expectations and experiences of clinical practice. Implementation of a Virtual Reality sensory room in a sub-acute ward for people living with dementia with behaviours and psychological symptoms associated with dementia (BPSD), Improved early diagnosis of eye diseases by integration of retinal photography and artificial intelligence to build an opportunistic screening service in metro, regional and remote primary care settings, In Vivo Tibiofemoral Biomechanics in Healthy Adults During Functional Activity, INDIGO Study: physical activity and goal-setting intervention for sedentary older adults at risk of cognitive decline, Principal Researcher Professor Nicola Lautenschlager (Melbourne Site), Research Group Leader Associate Professor Sheena Sullivan, Investigating the relationship between fat, bone and muscle, Marrow Adipose Tissue Functions: Studying Lipotoxicity in Hip Replacement Candidates, Mid-Life Determinants of Health in Older Age, Mid-Thigh Bone and Muscle Mass Measurements as an Assessment Tool for Diagnosis of Osteoporosis/penia, Sarcopenia and Osteosarcopenia: A Longitudinal Validation Study, Research Group Leader Professor Elizabeth Vincan. Ocular Biomarkers, Bioenergetics and Angiogenesis Research Group, Head of Laboratory Dr Peter van Wijngaarden, Head, Ocular Genetics Professor Paul N Baird, Professor of Ophthalmic Epidemiology Professor Mingguang He, Pacemaker channels and brain excitability, Perceptual Disturbance in younger onset dementia, Physical Activity, Sedentary Behaviour, and Cognition in Ageing Women, Predicting the onset of dementia using Positron Emission Tomography, Director of the Centre for Mental Health Professor Jane Pirkis, PROSPER: PRevalence Of unwanted Sexual contact: Pursuing Early Recognition, Proteomic profiles of psychotic symptom severity, Psychosis & Developmental Neuropsychiatry, Risk identification and Risk Assessment Framework, Safe Mothers, Safe Babies - Promoting safety and early parenting in high-risk relationships, Saving Brain and Changing Practice in Stroke, Self-help for Depression and Diabetes-related Distress in People With Type 2 Diabetes (SpringboarD), Project Leader (University of Melbourne) Professor Jane Gunn, Research Program Leader Professor Kelsey Hegarty, Single pulse electrical stimulation for epilepsy monitoring and tuning of DBS therapy, Smart wearable devices monitoring of intensive care patients, Stentrode: Tissue Response to Endovascular Stimulation, Stroke assessment with multi-modal imaging, Structural biology of proteins involved in mental illnesses, Studying brain-behaviour relationships during adolescence, Sudden Unexpected Death in Epilepsy (SUDEP), Project Lead Associate Professor Doug Crompton, Targeting microglia in neurodegenerative diseases, Principal Investigator A/Prof Victoria Palmer, The effect of anxiety on cardiovascular risk in healthy ageing women, The influence of sleep on brain development and psychopathology over adolescence, The neurobiology of anxiety across development and sex, The Neuropsychiatry of Androgen Deprivation, Chair of Psychiatrry Austin Health Professor Richard Kanaan, The role of the ubiquitin proteasome system in schizophrenia, Therapeutic Innovations in Affective Disorders, Healthscope Chair of Psychiatry Professor Chee Ng, Towards a patient-specific examination of epileptogenesis, Trying to stop Sudden Unexpected Death in EPilepsy (SUDEP), Project Leader Professor John Christodoulou, Understanding the neural basis of decision-making under uncertainty, Understanding the outcomes, including their language, participation and quality of life, of children with autism, Undestanding trajectories and biological underpinnings of children with autism who lose skills, Using systematic reviews to understand prognosis, diagnosis and effective interventions for children with neurodevelopmental difference and disability, When might the brain go wrong: the role of immune cells at critical time-points during development, WITH: Women’s Input to a Trauma-informed systems model of care in Health settings, Primary Investigator Professor Kelsey Hegarty. Medical Student Research Proposal Template The students who have gone above and beyond in 2020. Research framework [PDF 112KB] Research processes [PDF 112KB] Assessment types [PDF 133KB] Understanding P1 [PDF 233KB] Understanding E2 [PDF 132KB] Enterprise project questions Can We Fix Dementia with Deep Brain Stimulation? Discussions between the appropriate course co-ordinator, the academic supervisor and the student, determine the project finally undertaken. Sex, drugs and rock'n'roll: Young people and risk behaviours, Sexting, porn, and Tinder: An investigation of education and health promotion, Sexual and Reproductive Health in Adolescence, Director of Research Training Professor Meredith Temple-Smith, Sexual dysfunction in women who have experienced cancer, SUSTAIN: Sustainability of Identification and Response to Family Violence in antenatal care, Testing therapeutics for infertility in organoid models. For further information about this research, please contact a supervisor. Inflammatory mediators in the development of preeclampsia and pre-term birth. Projects may be in the clinical, social or basic medical sciences and may be conducted on campus or off-campus sites, nationally or internationally. The Faculty of Science Summer Research program offers research projects for students in the second or third year of their undergraduate degree, with associated scholarship opportunities.. Students gain an understanding of the research process, limitations and variability of data, and an application of research to clinical practice. Graduate Research application . Younger-onset dementia - carer mental health and service use. Our student projects offer opportunities to develop a range of skills in medical research, through tackling important research questions with the support of experienced mentors. The Department of Family Medicine and Community Health offers a number of research opportunities for fourth year medical students, including the university-wide Senior Scholars Program and a departmental Fourth Year Elective in Preventive Medicine and Public Health (both of these coordinated by Judy Savageau, MPH). For a list of potential student projects, please refer to the postgraduate research … Explore project topics ideas for physical sciences, engineering, life sciences, health sciences, social sciences, arts, management and medical sciences on ProjectTopics.org List of research project topics and materials sorted by subject to help with your final year projects The Ritchie Centre Our research projects are suitable for students with an interest in basic and clinical research studies for Honours (BSc, BBiomedSc and BMedSc), Masters and PhD. The program is a great way for you to gain research experience and an insight into research process while working alongside our leading scientific researchers. Identifying better therapies for patients with myelodysplastic syndromes. New opportunities for prevention of early delivery, Unravelling the Inflammatory Signatures of Paediatric Respiratory Disease, Using biomarkers and ultrasound in late pregnancy to minimise preventable stillbirth: the BUMPS study, Head of Research Group Professor Sue Walker, Utilizing technology to optimise ADHD care, Validation of automated blood pressure devices in children. -Stages of research projects Students often go into medicine because of a desire to help others and improve patients’ physical and mental wellbeing. Morphometric analysis of a Dravet Syndrome mouse model. A before and after study assessing the efficacy of a standardised hip fracture pathway in a tertiary trauma hospital, Adipocytes as Weapons of Bone Destruction: The bone as a War Zone, AgeHAPPY: Healthy Ageing Project Population Youth-senior, Principal investigator Professor Cassandra Szoeke, An exploration of the experience of care at the end of life for patients with a history of illicit drug use: A qualitative medical record review, Analysis of Synovial Fluid and Peripheral Blood Samples from Patients with Rheumatoid Arthritis and Using Patients with Osteoarthritis as Controls, Artificial intelligence in ophthalmology: from data to algorithm and real-world application, Artificial intelligence system to detect eye and cardiovascular diseases, Assessment of the Falls and Fractures Prevention Clinic as the Most Effective Setting toReduce Falls and Fractures in High-Risk Older Persons: A Care Program Assessment, Associations Between Sarcopenia, Intramuscular Fat, Mental/Physical Function and Brain Atrophy: An Imaging and Machine Learning Approach, Balance Gym for Falls Prevention in Older Adults, Characterization of Osteosarcopenia in Older Persons: A Bench to Bedside Approach, Circulating Osteogenic Precurors: Building Bone from Blood, Cognitive training for behavioural and psychological symptoms in young onset dementia, Dendritic cell cutaneous egression in Mycobacterium ulcerans infection. Team: Ellie Hajizadeh How does the periosteum control bone width? Medical Student Education. Project Lead Associate Professor Rachel Davey, Development of a Minimally Invasive Chronic Neural Interface, Group Leaders Dr Nicholas Opie and Dr Thomas Oxley, Development of Marrow Fat Quantification as a Predictor of Poor Outcomes in Osteosarcopenia, Dynamic microfluidic in vitro differentiation of stem cells for cartilage regeneration in surgical 3D bioprinting, Effect of HMB and Vitamin D Supplementation on osteosarcoPenia In oldeR pErsons (EMPIRE), Elucidating molecular signalling pathways controlled by anti-inflammatory steroids, Evaluating the impact of obesity on knee load over time in those who have undergone optimal surgical re-alignment after total knee replacement, Fighting disease with electricity: Vagus nerve stimulation as a treatment of arthritis, Generation of an ex vivo regeneration model for 3D bioprinting applications. What are the functional consequences of CDKL5 dysregulation in patient derived neuronal cells? Therapeutics Discovery and Vascular Function Group, Professor of Obstetrics and Gynaecology Professor Stephen Tong, Understanding the burden and consequences of Mycoplasma genitalium infection, Understanding the cause of human papillomavirus (HPV)-negative cervical cancers in Australian women, Understanding the genetic basis of lipedema, Faculty of Medicine, Dentistry and Health Sciences. Hugh Williamson Gait Laboratory/Orthopaedic Department, Research Group Leader Professor Kerr Graham, Identifying novel cartilage proteins with new functions, Inflammation-induced Osteosarcopenia: Mechanisms and Novel Treatments, Investigating Lipotoxic Impacts of Fatty Acid Synthesis on: (1) Osteoblasts, and (2) Osteoclast, in Vitro and (3) Skeletal Muscle, Investigating the Anabolic Effect Drugs (Picolinic Acid) on Osteocytes in Vitro, Investigating the Rapamycin Effect on Induced-Palmitic osteocytes in Vitro, Is muscle surgery or bone surgery better for young children with cerebral palsy who have hip displacement? Medical Student Research Projects Medical Student Research Projects. Research Group Leader Associate Professor Siddhartha Mahanty, Mapping the process of care in spinal cord injury: a substudy of the ICED trial, Mindfulness, cognitive processes and coping in chronic illness: insights from a study of joint replacement surgery. Effects of anticholinergic medications in hospitalised older patients discharged from geriatric rehabilitation wards, Effects of inappropriate medication use in frail older patients discharged from geriatric rehabilitation wards, Elucidating the functional roles of CCL17 in obesity-associated osteoarthritis, Emerging Infectious Diseases and Travel Medicine, Research Group Leader Dr Irani Thevarajan, Evaluating information resources for women considering elective egg freezing, Evidence-Based Practice in the Management of Glaucoma Suspects, Field tests for evaluation and prognostication in interstitial lung disease, Genotype and Phenotype Characterisation Human Circulating Osteo-Progenitor (COP) Cells. Treatment outcome in older lung cancer patients: does the biological age predict it? About us - Medical Student Education; Medical Student Education staff; External Medical Student Education electives; Prizes for medical students at Central Clinical School. Study a research degree with us The Deakin Medical School houses a vibrant program of research, including more than 100 research staff and over 100 research students. Students nominate a preferred research project during the first semester of 3rd year. A framework for creating subject-specific mathematical brain models, A novel biomarker strategy to predict neurogenerative disease risk, Academic Unit for Psychiatry of Old Age (AUPOA), Accelerated Gene Identification Program (Gene Discovery), Australian Centre for Cannabinoid Clinical and Research Excellence (ACRE): Quality and safety in the implementation of medicinal cannabis use in the community, Animal models of Brain Development assessed using histology, Animal models of Brain Development assessed using MRI, Anxiety and neurodegeneration in preclinical Alzheimer’s Disease, ARC Training Centre in Cognitive Computing for Medical Technologies, ARCADIA: Nutraceutical and Lifestyle Medicine Mental Health Research Group, Group Head and Honorary Principal Research Fellow Professor Jerome Sarris, Laboratory Head Professor Katrina Williams, Biomedical Engineering for Cochlear Implants, Chair of Psychiatry St Vincent's Mental Health Unit, Department of Psychiatry Professor David Castle, Brain development and the pathophysiology of psychosis, Brainwave and Electrophysiological Biomarkers of Cognition Enhancing Drugs, Building Early Attachment and Resiliance (BEAR) - an early intervention for parents and infants, Director, Centre for Women's Mental Health, Royal Women's Hospital Professor Louise Newman. Impact of risk-reducing bilateral salpingo-oophorectomy on non-cancer outcomes in young high-risk women: a multicentre prospective study. What role does the built environment play in the development of allergic diseases? Respiratory strategies to protect the preterm lung at birth, Reverse translation to better understand fetal growth restriction, Associate Professor Tu'uhevaha Kaitu'u-Lino, Rogerson Laboratory: Pathogenesis of malaria and immunity in children and pregnant women, Sexually transmitted infections and viral hepatitis, Short course antibiotic therapy for acute septic arthritis and haematogenous osteomyelitis in children, Stress Reactivity in Pre-schoolers with Congenital Heart Disease, Structural biology of proteins involved in infection, Supporting young people with complex disability to participate in important life situations, Surgical experience in paediatric gynaecology, Taking placenta to scale: The population burden of disordered placentation and placental function, The development of feeding in infants with oesophageal atresia between birth and nine months of age, The relationship between diet and mental health in children and young adults, The same but different: Transcriptional responses to inflammatory stimuli in phenotypically discordant monozygotic twins, Towards treatment of intellectual disability caused by errors in the chromatin machinery, Understanding and defining supportive health/NDIS service environments, Understanding family preferences for accessing mental healthcare for children with chronic physical health problems, Understanding hospital, GP, and family factors associated with paediatric asthma re-admissions, Understanding the importance of variation in the capsular polysaccharide of Streptococcus pneumoniae, Understanding the molecular basis of canvas-a novel neurological disorder caused by an expanded dna repeat, Understanding the pathogenesis of gestational diabetes, Understanding what triggers birth? Recruiting — indicates projects currently recruiting research students. Causes of Depressive Symptoms in Early Ageing, Centre for Women’s Mental Health Research, Cerebellar grey and white matter changes in children with Autism spectrum disorders, Cerebrospinal fluid (CSF) biomarkers in patients with vasospasm secondary to subarachnoid haemorrhage, Characterizing brain-body relationship with respect to biological aging in elderly population, Director, Mindful A/Professor Alessandra (Sandra) Radovini, Research Group Leader Assoc. What is the microbiological effect of a single dose of azithromycin given in labour? The School has a wide range of research expertise in the field of Public Health and Health Services Management. Cerebral oxygenation during neonatal intubation: an observational study, Changing the Trajectories of Australia's Most Vulnerable Children- The Early Years Education Program Randomised Controlled Trial, Characterisation of rotavirus strains emerging in the vaccine era, Characterising the genetic profile of gubernacular cells derived from androgen receptor knockout mice (ARKO) during testicular descent, Characterising the immune response to RSV in preterm and term infants, Clinical features in a common inherited cause of kidney failure, Cluster RCT of a multi-component intervention package to improve maternal and childhood vaccination in Victoria, Community Study of the Genetics of Autism Spectrum Disorder, Concussion Essentials: A clinical trial for reducing persisting symptoms after child concussion, Controlling nephron patterning and segmentation in kidney organoids, Defining the functional pathology of Hirschsprung Disease, Defining the mechanisms that underpin the beneficial off-target effects of BCG, Detection and prevention of tuberculosis in children and adolescents in endemic, resource-limited settings, Developing computational approaches to analyse development and disease, Developing high content screens of novel treatments for congenital nephrotic syndrome, Developing novel diagnosis methods for tree nut allergies, Developing novel methods for the diagnosis of tree nut allergies, Development of novel human stem cell derived models of beta-propeller protein-associated neurodegeneration for disease modelling and drug screening, Development of novel point-of-care diagnostics tests and surveillance tools for malaria, Development of novel vaccines against malaria, Discovering the mechanisms and targets of immunity against malaria, Discovery of new treatments for brain development disorders linked to epigenetic regulatory genes, Dose optimisation of antibiotics in children with cystic fibrosis, Effect of congenital UDT on Gonocyte development, Effects of Vitamin D Status on DEXA Femoral Neck BMD in Children and Adolescents, Effects of Vitamin D Status on Forearm Fracture Healing Rates in Children and Adolescents: A Pilot Study, Research Group Leader Professor Jodie McVernon, Evaluating health outcomes of transgender children and adolescents, Expression systems for pluripotent stem cells and their differentiated derivatives, Family Study of the Genetics of Autism Spectrum Disorder, Fertility preservation in adolescent and young adult cancer survivors, Research Group Leader Professor Sylvia Metcalfe, Research Group Leader Professor Beverley Ann-Biggs, Gut epithelial stem cell function: the influence of enteric neurons, Healthy Mothers, Healthy Babies in Papua New Guinea – The impact of nutrition, malaria, and other infections on pregnant women and infants. 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